Ward Timothy R, Turunen Brandon J, Haack Torsten, Neuenswander Benjamin, Shadrick William, Georg Gunda I
Department of Medicinal Chemistry and Center for Methodology and Library Development, University of Kansas, 1251 Wescoe Hall Drive, Lawrence Kansas 66045, USA; Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA.
Tetrahedron Lett. 2009 Nov 25;50(47):6494-9497. doi: 10.1016/j.tetlet.2009.09.024.
A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.
利用炔酮中间体，由取代邻氨基苯甲酸合成了一个包含72种喹诺酮的文库。这些掩蔽的β-二羰基合成子使得环化反应能在比先前报道的喹诺酮合成更温和的条件下进行。
