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硼酸介导的高效α-羟基酰胺制备方法。

An Efficient Boric Acid Mediated Preparation of α-Hydroxyamides.

作者信息

Kumar J Sravan, Jonnalagadda Subash C, Mereddy Venkatram R

机构信息

Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN 55812.

出版信息

Tetrahedron Lett. 2010 Feb 3;51(5):779-782. doi: 10.1016/j.tetlet.2009.12.008.

DOI:10.1016/j.tetlet.2009.12.008
PMID:20161580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2808032/
Abstract

An efficient methodology for the preparation of α-hydroxyamides via boric acid mediated addition of isonitriles on to aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.

摘要

已经开发出一种通过硼酸介导异腈加成到醛上制备α-羟基酰胺的有效方法。异腈与α-硼苯甲醛的反应在分子内催化条件下进行，以提供功能化的苯并硼氧六元环。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/2808032/52a857643652/nihms-163447-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/2808032/52a857643652/nihms-163447-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81e1/2808032/52a857643652/nihms-163447-f0001.jpg

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