Kumar J Sravan, Jonnalagadda Subash C, Mereddy Venkatram R
Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN 55812.
Tetrahedron Lett. 2010 Feb 3;51(5):779-782. doi: 10.1016/j.tetlet.2009.12.008.
An efficient methodology for the preparation of α-hydroxyamides via boric acid mediated addition of isonitriles on to aldehydes has been developed. The reaction of isonitriles with α-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles.
已经开发出一种通过硼酸介导异腈加成到醛上制备α-羟基酰胺的有效方法。异腈与α-硼苯甲醛的反应在分子内催化条件下进行,以提供功能化的苯并硼氧六元环。