Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3550 Market Street, Philadelphia, PA 19104, USA.
Expert Rev Clin Immunol. 2010 Jan;6(1):101-9. doi: 10.1586/eci.09.74.
Eosinophilic esophagitis (EE) has an increased incidence of diagnosis similar to other atopic diseases. We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar features with the importance of T cells and Th2 cytokines for the development of disease. The diseases share underlying inflammation with the potential for remodeling with an increase in TGF-beta expression in asthma and EE. However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids.
嗜酸性食管炎（EE）的诊断发病率与其他特应性疾病相似。我们最近对特应性疾病（即哮喘、过敏性鼻炎和特应性皮炎）和 EE 之间的共同特征进行了文献回顾。所有这些疾病都有过敏原触发，并在疾病部位有 Th2 炎症的证据。鼠类模型也表现出类似的特征，T 细胞和 Th2 细胞因子对疾病的发展很重要。这些疾病具有潜在的炎症，具有潜在的重塑，哮喘和 EE 中 TGF-β表达增加。然而，这些疾病在治疗和发病机制上确实存在差异。对于 EE，有两种基本的治疗选择：避免食物触发或用皮质类固醇治疗嗜酸性粒细胞炎症。
