Dupuis Pascale, Prokopich C Lisa, Hynes Alexander, Kim Harold
1Division of Clinical Immunology and Allergy, Department of Medicine, St. Joseph's Hospital, Western University, Room B3-102, 268 Grosvenor Street, London, ON N6A 4V2 Canada.
2School of Optometry & Vision Science, University of Waterloo, 200 Columbia St W., Waterloo, ON N2L 3G1 Canada.
Allergy Asthma Clin Immunol. 2020 Jan 21;16:5. doi: 10.1186/s13223-020-0403-9. eCollection 2020.
Allergic eye disease is common, yet often overlooked in North America. In the U.S., up to 40% of the population is deemed to be affected and this number is growing. Symptoms and signs of ocular allergy can lead to decreased productivity and negatively impact quality of life (QoL). Various treatment options exist to achieve symptom control. For allergic conjunctivitis, ophthalmic agents include antihistamines, mast cell stabilizers, dual-activity agents, nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and some off-label treatments. Immunotherapy is recommended as a therapeutic option. This review provides a summary of the forms of ocular allergies, with a focus on symptoms and signs, impact on QoL, physical examination, diagnosis and therapeutic options of allergic conjunctivitis. Through multidisciplinary collaborations, a simplified algorithm for the treatment of allergic conjunctivitis is proposed for Canadian clinical practice.
过敏性眼病很常见，但在北美常常被忽视。在美国，高达40%的人口被认为受到影响，而且这个数字还在增长。眼部过敏的症状和体征会导致生产力下降，并对生活质量（QoL）产生负面影响。有多种治疗选择可实现症状控制。对于过敏性结膜炎，眼科药物包括抗组胺药、肥大细胞稳定剂、双重作用药物、非甾体抗炎药（NSAIDs）、类固醇以及一些非标签治疗方法。免疫疗法被推荐作为一种治疗选择。本综述总结了眼部过敏的形式，重点关注过敏性结膜炎的症状和体征、对生活质量的影响、体格检查、诊断和治疗选择。通过多学科合作，为加拿大临床实践提出了一种简化的过敏性结膜炎治疗算法。
