精神分裂症中思维紊乱以及语言和交流障碍的遗传基础。
The Genetic Basis of Thought Disorder and Language and Communication Disturbances in Schizophrenia.
作者信息
Levy Deborah L, Coleman Michael J, Sung Heejong, Ji Fei, Matthysse Steven, Mendell Nancy R, Titone Debra
机构信息
Psychology Research Laboratory, McLean Hospital, Belmont, MA, USA.
出版信息
J Neurolinguistics. 2010 May 1;23(3):176. doi: 10.1016/j.jneuroling.2009.08.003.
Thought disorder as well as language and communication disturbances are associated with schizophrenia and are over-represented in clinically unaffected relatives of schizophrenics. All three kinds of dysfunction involve some element of deviant verbalizations, most notably, semantic anomalies. Of particular importance, thought disorder characterized primarily by deviant verbalizations has a higher recurrence in relatives of schizophrenic patients than schizophrenia itself. These findings suggest that deviant verbalizations may be more penetrant expressions of schizophrenia susceptibility genes than schizophrenia. This paper reviews the evidence documenting the presence of thought, language and communication disorders in schizophrenic patients and in their first-degree relatives. This familial aggregation potentially implicates genetic factors in the etiology of thought disorder, language anomalies, and communication disturbances in schizophrenia families. We also present two examples of ways in which thought, language and communication disorders can enrich genetic studies, including those involving schizophrenia.
思维紊乱以及语言和交流障碍与精神分裂症相关，并且在精神分裂症患者临床未受影响的亲属中表现更为突出。这三种功能障碍都涉及某种异常言语表达的成分，最显著的是语义异常。特别重要的是，主要以异常言语表达为特征的思维紊乱在精神分裂症患者亲属中的复发率高于精神分裂症本身。这些发现表明，异常言语表达可能比精神分裂症更能体现精神分裂症易感性基因的显性表达。本文综述了证明精神分裂症患者及其一级亲属存在思维、语言和交流障碍的证据。这种家族聚集现象可能意味着遗传因素在精神分裂症家族中思维紊乱、语言异常和交流障碍的病因中起作用。我们还给出了两个例子，说明思维、语言和交流障碍如何能够丰富基因研究，包括那些涉及精神分裂症的研究。
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