Coondoo Arijit
Department of Dermatology, Vivekananda Institute of Medical Science, Kolkata, India.
Indian J Dermatol. 2009 Jul;54(3):211-20. doi: 10.4103/0019-5154.55627.
Biologics are protein molecules which are used in various diseases to target the specific points in the immunopathogenesis of the diseases. The molecules are produced by recombinant DNA technology. The molecules bind to the specific targets without interfering wtih rest of the pathogenetic pathways. Therefore the so called 'immunosuppressives' have, although, a broader broader spectrum of action on immune system, their side-effects are also equally more. The biologics, because of their spefic action on the immune system, have very little side effects. The biologics which have revolutionized the treatment of various dermatologic diseases have been discussed here.
生物制剂是蛋白质分子，用于多种疾病，以针对疾病免疫发病机制中的特定靶点。这些分子通过重组DNA技术生产。它们与特定靶点结合，而不干扰其余的致病途径。因此，所谓的“免疫抑制剂”虽然对免疫系统有更广泛的作用谱，但其副作用也同样更多。生物制剂由于对免疫系统具有特异性作用，副作用非常小。本文讨论了彻底改变各种皮肤病治疗方法的生物制剂。
