Ogbole O O, Ekor M N, Oluremi B B, Ajaiyeoba E O, Gbolade A A, Ayoola M A, Adeyemi A A
Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria.
Afr J Tradit Complement Altern Med. 2007 Feb 16;4(3):372-6.
The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants.
对印度希波克拉底树（Hippocratea indica）根皮和油加耶籽（Poga oleosa）果实的甲醇提取物进行了抗炎和抗菌活性研究。两种提取物在4小时内均以剂量依赖性方式显著抑制了角叉菜胶诱导的大鼠爪部水肿。印度希波克拉底树从2小时起在最小剂量（125毫克/毫升，p<0.05）时就显著抑制水肿，在250毫克/千克时4小时内产生100%的抑制作用。结果表明它是比油加耶籽更有效的抗炎剂。此外，印度希波克拉底树提取物对受试细菌表现出更强的抗菌活性，金黄色葡萄球菌是最敏感的细菌（最低抑菌浓度，16毫克/毫升）。两种植物对白色念珠菌均无活性。这些结果证实了这两种植物的抗炎和抗菌活性。
