对具有民族植物学重要性的药用植物茎皮进行抗菌筛选。
Antimicrobial screening of ethnobotanically important stem bark of medicinal plants.
作者信息
Singh Meenakshi, Khatoon Sayyada, Singh Shweta, Kumar Vivek, Rawat Ajay Kumar Singh, Mehrotra Shanta
机构信息
Mimansha Herbals, 25, Basant Vihar, Indira Nagar, Lucknow, India.
出版信息
Pharmacognosy Res. 2010 Jul;2(4):254-7. doi: 10.4103/0974-8490.69127.
BACKGROUND
The stem barks are the rich sources of tannins and other phenolic compounds. Tannins inhibited the growth of various fungi, yeast, bacteria and virus. Hence, ten stem barks of ethnomedicinally important plants were screened for antibacterial and antifungal activities against human pathogenic strains.
METHODS
Air-dried and powdered stem bark of each plant was extracted with 50% aqueous ethanol, lyophilized and the dried crude extracts were used for the screening against 11 bacteria and 8 fungi. Antibacterial and antifungal activities were performed according to microdilution methods by NCCLS.
RESULTS
The plants Prosopis chilensis, Pithecellobium dulce, Mangifera indica showed significant antibacterial and antifungal activities against Streptococcus pneumonia, Enterobacter aerogenes, Klebsiella pneumonia and Candida albicans with MIC of 0.08mg/ml. Pithecellobium dulce bark also showed significant antibacterial activity against Bacillus cereus.
CONCLUSION
The bark of Pithecellobium dulce has more or less similar activity against the known antibiotic and may be considered as potent antimicrobial agent for various infectious diseases.
背景
茎皮是单宁及其他酚类化合物的丰富来源。单宁可抑制多种真菌、酵母、细菌和病毒的生长。因此，对10种具有民族药用价值的植物的茎皮进行了筛选，以检测其对人类致病菌株的抗菌和抗真菌活性。
方法
将每种植物的风干茎皮粉末用50%乙醇水溶液提取，冻干，所得干燥粗提物用于对11种细菌和8种真菌的筛选。抗菌和抗真菌活性根据美国国家临床实验室标准委员会（NCCLS）的微量稀释法进行检测。
结果
智利牧豆树、甜荚豆、芒果对肺炎链球菌、产气肠杆菌、肺炎克雷伯菌和白色念珠菌表现出显著的抗菌和抗真菌活性，最低抑菌浓度（MIC）为0.08mg/ml。甜荚豆树皮对蜡样芽孢杆菌也表现出显著的抗菌活性。
结论
甜荚豆树皮对已知抗生素具有或多或少相似的活性，可被视为治疗各种传染病的有效抗菌剂。
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