非洲陀螺果根皮对正常及四氧嘧啶诱导的糖尿病大鼠的降血糖作用
Hypoglycemic effect of Treculia africana Decne root bark in normal and alloxan-induced diabetic rats.
作者信息
Oyelola O O, Moody J O, Odeniyi M A, Fakeye T O
机构信息
Laboratory of Ecological Chemistry, Division of Applied Biosciences, Graduate School of Agriculture, Hokkaido University, Kita 9 Nishi 9, Sapporo 060-8589, Japan.
出版信息
Afr J Tradit Complement Altern Med. 2007 Jun 10;4(4):387-91. doi: 10.4314/ajtcam.v4i4.31233.
The solvent partitioned purified fractions of the hydro-acetone root bark extract of the African breadfruit (Treculia africana Decne) were evaluated for hypoglycemic activities in normal and diabetic albino rats. Fasting blood glucose levels were estimated by the use of a glucometer at pre-determined intervals after oral administration of the test extracts/fractions. Results revealed that the test fractions have only a slight effect on blood sugar level of normal rats. On short term and chronic administration in diabetic rats however, diethyl ether-soluble (DEF) and the water-soluble (WSF) fractions significantly reduced the fasting blood sugar levels (p<0.05) at differing rates when compared with the control group of animals. The diethyl ether soluble fraction (10 mg kg(-1) dose level) was found to exhibit the highest activity giving 69.4% reduction in blood sugar level (at 240 hours) which was in comparable range with the reference standard glibenclamide (0.5 mg kg(-1)) which reduced blood sugar levels by 65.8% below the initial baseline values.
对非洲面包树（Treculia africana Decne）水-丙酮根皮提取物经溶剂分配纯化后的各组分，在正常和糖尿病白化大鼠中进行了降血糖活性评估。口服给予受试提取物/组分后，在预定时间间隔使用血糖仪测定空腹血糖水平。结果显示，受试组分对正常大鼠的血糖水平仅有轻微影响。然而，在糖尿病大鼠中进行短期和长期给药时，与动物对照组相比，二乙醚可溶组分（DEF）和水溶性组分（WSF）以不同速率显著降低了空腹血糖水平（p<0.05）。发现二乙醚可溶组分（剂量水平为10 mg kg(-1)）表现出最高活性，血糖水平降低了69.4%（在240小时时），这与参考标准格列本脲（0.5 mg kg(-1)）相当，后者使血糖水平比初始基线值降低了65.8%。
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