Kouitcheu Mabeku Laure B, Kouam J, Penlap Beng V, Ngadjui Bonaventure T, Fomum Z T, Etoa F X
Laboratory of the Applied Microbiology and Molecular Pharmacology, Department of Biochemistry, Faculty of Science, P. O. Box 812, University of Yaoundé I, Cameroon.
Afr J Tradit Complement Altern Med. 2006 Aug 28;4(1):87-93. doi: 10.4314/ajtcam.v4i1.31197.
Ethyl acetate (EA) extract of the stem bark of Cylicodiscus gabunensis (CG) was analysed phytochemically and evaluated for its antimicrobial activity against 17 pathogenic species isolated from patient: Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, Shigella flexneri, Morganella morganii, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Citrobacter freundii, Enterobacter cloacae, Enterobacter agglomerans, Staphylococcus aureus, Streptococcus feacalis, Pseudomonas aeruginosa, Bacillus cereus T, Candida albicans and Candida glabrata. Flavonoids, saponins, tannins, polyphenols, coumarins, triterpenes and/or sterols and reducing sugars were detected in the (EA) extract of CG. The best MIC and MBC values for the microorganisms sensitive to the extract were 0.00078 and 0.00315 mg/ml respectively. The greater and remarkable antimicrobial activity of the (EA) extract of CG was recorded with Staphylococcus aureus, Proteus vulgaris and Bacillus cereus T. These results provide a rationalization for the traditional use of this plant for the treatment of infectious diseases.
对加蓬旋柱麻（Cylicodiscus gabunensis，CG）茎皮的乙酸乙酯（EA）提取物进行了植物化学分析，并评估了其对从患者分离出的17种致病菌种的抗菌活性，这些菌种包括：大肠杆菌、肺炎克雷伯菌、痢疾志贺菌、福氏志贺菌、摩根摩根菌、普通变形杆菌、奇异变形杆菌、伤寒沙门菌、弗氏柠檬酸杆菌、阴沟肠杆菌、聚团肠杆菌、金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、蜡样芽孢杆菌T、白色念珠菌和光滑念珠菌。在CG的（EA）提取物中检测到了黄酮类化合物、皂苷、单宁、多酚、香豆素、三萜和/或甾醇以及还原糖。对该提取物敏感的微生物的最佳最低抑菌浓度（MIC）和最低杀菌浓度（MBC）值分别为0.00078和0.00315 mg/ml。CG的（EA）提取物对金黄色葡萄球菌、普通变形杆菌和蜡样芽孢杆菌T表现出更强且显著的抗菌活性。这些结果为该植物传统上用于治疗传染病提供了合理依据。
