Taziebou Lienou C, Etoa F-X, Nkegoum B, Pieme C A, Dzeufiet D P D
Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, P. O. Box 812, University of Yaounde I, Cameroon.
Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):127-34.
This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity, 5 doses of 2, 4, 8, 12 and 16 g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver, kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD(50)) was found to be greater in females than males with an average of 6.6 g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT, AST, ALP, Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand, most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity.
本研究旨在评估非洲黏冠草叶片水提取物的毒性。以500毫克/千克和1000毫克/千克的口服剂量，每2天给大鼠给药一次，持续28天，以进行亚急性毒性试验。对于急性毒性试验，在小鼠中研究了5个剂量，分别为2、4、8、12和16克/千克体重。对照组由给予蒸馏水的小鼠或大鼠组成。在整个实验过程中，不同哺乳动物的中毒迹象略有波动。大鼠的肝脏、肾脏和心脏重量在试验组和对照组之间没有显著差异。结果表明，雌性的半数致死剂量（LD(50)）高于雄性，两性平均为6.6克/千克体重。尽管在某些生化参数（谷丙转氨酶、谷草转氨酶、碱性磷酸酶、肌酐和谷胱甘肽）的某些点上观察到显著差异，但均未显示出任何线性剂量反应性。另一方面，发现大多数研究参数存在性别依赖性。这些结果表明，非洲黏冠草可归类为低毒物质。
