Biommeda, IBiTech, Ghent University, Ghent, Belgium.
Med Biol Eng Comput. 2010 Apr;48(4):371-80. doi: 10.1007/s11517-010-0583-4. Epub 2010 Feb 17.
Patient-specific simulations are widely used to investigate the local hemodynamics within realistic morphologies. However, pre-processing and mesh generation are time consuming, operator dependent, and the quality of the resulting mesh is often suboptimal. Therefore, a semi-automatic methodology for patient-specific reconstruction and structured meshing of a left coronary tree from biplane angiography is presented. Seven hexahedral grids have been generated with the new method (50,000-3,200,000 cells) and compared to nine unstructured tetrahedral grids with prismatic boundary layer (150,000-3,100,000 cells). Steady-state blood flow simulation using Computational Fluid Dynamics (CFD) has been used to calculate the Wall Shear Stress (WSS). Our results (99 percentile, area-weighted and local WSS values along a line) demonstrate that hexahedral meshes with respect to tetrahedral/prismatic meshes converge better, and for the same accuracy of the result, six times less cells and 14 times less computational time are required. Hexahedral meshes are superior to tetrahedral/prismatic meshes and should be preferred for the calculation of the WSS.
患者特定模拟广泛用于研究真实形态内的局部血液动力学。然而，预处理和网格生成既耗时又依赖于操作人员，并且生成的网格质量通常不理想。因此，提出了一种从双平面血管造影术进行左冠状动脉树的患者特定重建和结构化网格的半自动方法。使用新方法生成了七个六面体网格（50,000-3,200,000 个单元），并与九个具有棱柱边界层的非结构化四面体网格（150,000-3,100,000 个单元）进行了比较。使用计算流体动力学（CFD）进行稳态血流模拟以计算壁面剪切应力（WSS）。我们的结果（99 百分位，加权面积和沿一条线的局部 WSS 值）表明，六面体网格相对于四面体/棱柱体网格收敛得更好，并且对于相同的结果精度，所需的单元数减少六倍，计算时间减少十四倍。六面体网格优于四面体/棱柱体网格，应优先用于计算 WSS。
