Buff D D, Brenner R, Kirtane S S, Gilboa R
Division of Geriatrics, St. John's Episcopal Hospital, Far Rockaway, N.Y. 11691.
J Clin Psychiatry. 1991 Apr;52(4):174-6.
Although fluoxetine has been shown to be both efficacious and well tolerated, few data are available on the use of this drug in patients with preexisting heart disease and in the elderly. The authors report a case of an elderly patient in whom atrial fibrillation and bradycardia developed shortly after she began treatment with fluoxetine. The dysrhythmias recurred on rechallenge with the drug. A review of the pertinent literature is presented and possible pathophysiologic mechanisms are discussed.
尽管氟西汀已被证明有效且耐受性良好，但关于该药在已有心脏病患者和老年患者中的应用数据却很少。作者报告了一例老年患者，该患者在开始使用氟西汀治疗后不久出现了心房颤动和心动过缓。再次使用该药物时心律失常复发。本文对相关文献进行了综述，并讨论了可能的病理生理机制。
