Department of Psychiatry, University of Jena, Germany.
Hum Brain Mapp. 2010 Dec;31(12):1834-50. doi: 10.1002/hbm.20980. Epub 2010 Feb 16.
Evidence suggests that obsessive compulsive disorder (OCD) is associated with an overactive error control system. A key role in error detection and control has been ascribed to the fronto-cingulate system. However, the exact functional interplay between the single components of this network in OCD is largely unknown. Therefore, the present study combined a univariate data analysis and effective connectivity analysis using dynamic causal modeling (DCM) to examine error control in 21 patients with OCD and 21 matched healthy controls. All subjects performed an adapted version of the Stroop color-word task while undergoing fMRI scans. Enhanced activation in the fronto-cingulate system could be detected in OCD patients during the incongruent task condition. Additionally, task-related modulation of effective connectivity from the dorsal ACC to left DLPFC was significantly stronger in OCD patients. These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making.
证据表明，强迫症（OCD）与过度活跃的错误控制系统有关。额顶叶系统在错误检测和控制中起着关键作用。然而，在 OCD 中，该网络的单个组件之间的确切功能相互作用在很大程度上尚不清楚。因此，本研究结合了单变量数据分析和使用动态因果建模（DCM）的有效连通性分析，以检查 21 名 OCD 患者和 21 名匹配的健康对照者的错误控制。所有受试者在进行 fMRI 扫描时都执行了改编版的 Stroop 颜色-单词任务。在不相符任务条件下，可在 OCD 患者中检测到额顶叶系统的增强激活。此外，在 OCD 患者中，从背侧 ACC 到左 DLPFC 的有效连接的任务相关调制明显更强。这些发现与 OCD 中过度活跃的错误控制系统一致，该系统在决策过程中抑制了优势反应。
