Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Chemphyschem. 2010 Apr 6;11(5):1029-35. doi: 10.1002/cphc.200900914.
The use of mesoporous silicon particles for drug delivery has been widely explored thanks to their biodegradability and biocompatibility. The ability to tailor the physicochemical properties of porous silicon at the micro- and nanoscale confers versatility to this material. A method for the fabrication of highly reproducible, monodisperse, mesoporous silicon particles with controlled physical characteristics through electrochemical etching of patterned silicon trenches is presented. The particle size is tailored in the micrometer range and pore size in the nanometer range, the shape from tubular to discoidal to hemispherical, and the porosity from 46 to over 80%. In addition, the properties of the porous matrix are correlated with the loading of model nanoparticles (quantum dots) and their three-dimensional arrangement within the matrix is observed by transmission electron microscopy tomography. The methods developed in this study provide effective means to fabricate mesoporous silicon particles according to the principles of rational design for therapeutic vectors and to characterize the distribution of nanoparticles within the porous matrix.
得益于其生物降解性和生物相容性，介孔硅颗粒在药物输送中的应用得到了广泛的探索。通过对图案化硅沟槽进行电化学刻蚀，可以在微纳尺度上定制多孔硅的物理化学性质，从而赋予该材料多功能性。本文提出了一种通过电化学刻蚀图案化硅沟槽来制备具有高度重现性、单分散性、可控物理特性的介孔硅颗粒的方法。颗粒尺寸可在微米范围内调节，孔径在纳米范围内，形状从管状到盘状到半球形，孔隙率从 46%到 80%以上。此外，多孔基质的性能与模型纳米粒子（量子点）的负载相关，并且通过透射电子显微镜断层扫描观察到它们在基质中的三维排列。本研究中开发的方法为根据治疗载体的合理设计原则制备介孔硅颗粒并对纳米颗粒在多孔基质中的分布进行表征提供了有效的手段。
