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细胞膜包覆仿生递送系统的研究进展

Research Progress on Cell Membrane-Coated Biomimetic Delivery Systems.

作者信息

Guo Mengyu, Xia Chenjie, Wu Yu, Zhou Nong, Chen Zhipeng, Li Weidong

机构信息

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Front Bioeng Biotechnol. 2021 Nov 16;9:772522. doi: 10.3389/fbioe.2021.772522. eCollection 2021.

DOI:10.3389/fbioe.2021.772522
PMID:34869288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8636778/
Abstract

Cell membrane-coated biomimetic nanoplatforms have many inherent properties, such as bio-interfacing abilities, self-identification, and signal transduction, which enable the biomimetic delivery system to escape immune clearance and opsonization. This can also maximize the drug delivery efficiency of synthetic nanoparticles (NPs) and functional cell membranes. As a new type of delivery system, cell membrane-coated biomimetic delivery systems have broadened the prospects for biomedical applications. In this review, we summarize research progress on cell membrane biomimetic technology from three aspects, including sources of membrane, modifications, and applications, then analyze their limitations and propose future research directions.

摘要

细胞膜包覆的仿生纳米平台具有许多固有特性，如生物界面能力、自我识别和信号转导，这些特性使仿生递送系统能够逃避免疫清除和调理作用。这还可以使合成纳米颗粒（NPs）和功能性细胞膜的药物递送效率最大化。作为一种新型递送系统，细胞膜包覆的仿生递送系统拓宽了生物医学应用的前景。在本综述中，我们从膜的来源、修饰和应用三个方面总结了细胞膜仿生技术的研究进展，然后分析了它们的局限性并提出了未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/e8d8adc49962/fbioe-09-772522-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/a8739388c327/fbioe-09-772522-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/d8e36e4ce82b/fbioe-09-772522-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/dc9f0b3439e2/fbioe-09-772522-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/e8d8adc49962/fbioe-09-772522-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/a3b42550e326/fbioe-09-772522-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/2aa61591b8c7/fbioe-09-772522-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/e0c091fd2be8/fbioe-09-772522-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/a8739388c327/fbioe-09-772522-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/4f48f69e9bbc/fbioe-09-772522-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/8f7533010da5/fbioe-09-772522-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/f041bbfcfc8e/fbioe-09-772522-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/d8e36e4ce82b/fbioe-09-772522-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/dc9f0b3439e2/fbioe-09-772522-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d563/8636778/e8d8adc49962/fbioe-09-772522-g010.jpg

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Nanomicro Lett. 2019 Nov 16;11(1):100. doi: 10.1007/s40820-019-0330-9.
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Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy.用于药物递送和癌症治疗的细胞介导及细胞膜包被纳米颗粒。
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