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农药、淡水鱼、肝吸虫与亚硝胺:泰国胆管癌发病的故事

Pesticides, fresh water fish, liver flukes and nitrosamines: A story of cholangiocarcinoma development in Thailand.

作者信息

Wiwanitkit Viroj

机构信息

Wiwanitkit House, Bangkhae, Bangkok, Thailand.

出版信息

Asian Pac J Cancer Prev. 2009;10(5):961-2.

PMID:20162855
Abstract

Cholangiocarcinoma is a common hepatobiliary carcinoma in Thailand. It is believed that both chronic exposure to liver fluke infestation and nitrosamine exposure are the two main underlying factors leading to the carcinogenesis. Here, the author further extrapolates and proposes a new hypothesis based on the environmental ecological data that the stimulation of fresh water fish by contaminated pesticide in water reservoirs might be a possible background of the high prevalence of cholangiocarcinoma in Thailand.

摘要

胆管癌是泰国一种常见的肝胆癌。人们认为,长期接触肝吸虫感染和亚硝胺暴露是导致致癌的两个主要潜在因素。在此,作者根据环境生态数据进一步推断并提出了一个新假说,即水库中受污染农药对淡水鱼的刺激可能是泰国胆管癌高发病率的一个潜在背景。

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Significant response to anti-PD-1 based immunotherapy plus lenvatinib for recurrent intrahepatic cholangiocarcinoma with bone metastasis: A case report and literature review.抗程序性死亡蛋白1(PD-1)免疫疗法联合乐伐替尼治疗复发性肝内胆管癌伴骨转移的显著疗效:一例报告及文献综述
Medicine (Baltimore). 2019 Nov;98(45):e17832. doi: 10.1097/MD.0000000000017832.
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