Department of Community Medicine, Dr Dy Patil University, Pune, Maharashtra, India; Department of Biological Science, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun, Nigeria; Department of Medical Science, Faculty of Medicine, University of Nis, Serbia; Department of Laboratory Medicine, Chulalongkorn University, Bangkok, Thailand.
J Cancer Res Ther. 2022 Jul-Sep;18(4):927-930. doi: 10.4103/jcrt.JCRT_783_19.
Parasitic-induced cancer is an important problem in tropical oncology. Liver fluke-related biliary tract cancer of cholangiocarcinoma is an important kind of endemic cancer in Southeast Asia. This cancer is related to the liver fluke infection. The local public health policies for disease control include antiparasitic drug, praziquantel, distributing aiming at getting rid of risk factor, and opisthorchiasis. In the present report, the authors reappraise on the local epidemiological data on liver fluke infection among the local people in endemic area Thailand under antiparasitic drug distribution program for further assessment for expected rate of cholangiocarcinoma.
The present study is a clinical mathematical modeling study. First, the retrospective reappraisal on the available local data on liver fluke infection among the local people in endemic area of Thailand, a tropical country in Indochina, with a different history of previous exposure to antiparasitic drug is done. Then, a mathematical model based on predictive modeling and probability assignment technique is developed for the assessment of estimated rate of cholangiocarcinoma.
According to the present study, the expected rate of liver fluke-related cholangiocarcinoma is equal to 0.0564%. There is a strong relationship between expected rate of liver fluke-related cholangiocarcinoma and number of previous exposure to praziquantel (r = 0.99, P = 0.02).
According to the study, the high expected rare of cholangiocarcinoma is observed despite the use of general antiparasitic drug distribution policy. It implies finding for new adjusted public health manipulation for disease prevention and management.
寄生虫引起的癌症是热带肿瘤学的一个重要问题。肝吸虫相关胆管癌是东南亚一种重要的地方癌。这种癌症与肝吸虫感染有关。针对消除危险因素的驱虫药吡喹酮，当地公共卫生疾病控制政策包括地方性肝吸虫病。在本报告中，作者重新评估了在驱虫药分发计划下，地方性肝吸虫感染的当地人群的地方流行性病学数据，以进一步评估胆管癌的预期发生率。
本研究是一项临床数学建模研究。首先，对来自于东南亚热带国家泰国地方性肝吸虫病流行地区的当地人群的肝吸虫感染的现有地方数据进行回顾性重新评估，这些地区有着不同的过去驱虫药暴露史。然后，基于预测模型和概率赋值技术开发了一种数学模型，用于评估胆管癌的估计发生率。
根据本研究，肝吸虫相关胆管癌的预期发生率等于 0.0564%。肝吸虫相关胆管癌的预期发生率与先前接触吡喹酮的次数之间存在很强的关系（r = 0.99，P = 0.02）。
尽管使用了一般的驱虫药分发政策，但研究观察到了胆管癌的高预期发生率。这表明需要寻找新的调整后的公共卫生管理措施来预防和管理疾病。
