Division of Perinatal Research, Department of Obstetrics, Gynecology and Women's Health, University of Missouri-Columbia, MO 65201, USA.
Am J Reprod Immunol. 2010 Jun;63(6):460-71. doi: 10.1111/j.1600-0897.2010.00813.x. Epub 2010 Feb 16.
Macrophages represent one of the major leukocyte subsets in the uterine decidua. Owing to their remarkable phenotypic plasticity, decidual macrophages can participate in diverse activities during pregnancy. At baseline, decidual macrophages are characterized by an immunosuppressive phenotype and M2 polarization, supporting feto-maternal immune tolerance. In early pregnancy, macrophage-derived pro-angiogenic factors prompt vascular remodeling within the uterine wall to ensure appropriate utero-placental circulation. Upon invasion by pathogens, pattern recognition receptors on decidual macrophages help to alter the characteristics of these malleable cells toward an M1, inflammatory phenotype. Similar inflammatory characteristics are seen in those macrophages that accumulate in the lower segment of the uterus to drive cervical ripening. Disturbances in the tight control that balances macrophage function during pregnancy can trigger the development of pregnancy complications. Here, we discuss the physiologic role of uterine macrophages at different stages of pregnancy and describe their relevance in selected pregnancy disorders.
巨噬细胞是子宫蜕膜中主要的白细胞亚群之一。由于其显著的表型可塑性，蜕膜巨噬细胞可以在怀孕期间参与多种活动。在基础状态下，蜕膜巨噬细胞表现出免疫抑制表型和 M2 极化，支持胎母免疫耐受。在早孕期间，巨噬细胞衍生的促血管生成因子促使子宫壁内的血管重塑，以确保适当的子宫胎盘循环。当病原体入侵时，蜕膜巨噬细胞上的模式识别受体有助于改变这些可塑细胞的特征，使其向 M1 炎症表型转变。在那些聚集在子宫下段以促进宫颈成熟的巨噬细胞中也可以看到类似的炎症特征。怀孕期间对巨噬细胞功能的严格控制失衡会引发妊娠并发症的发展。在这里，我们讨论了在妊娠不同阶段子宫巨噬细胞的生理作用，并描述了它们在一些妊娠疾病中的相关性。
