Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan.
Anim Sci J. 2009 Jun;80(3):291-5. doi: 10.1111/j.1740-0929.2009.00626.x.
Recently, we reported that intracerebroventricular (i.c.v.) injection of reduced glutathione (GSH) induces hypnotic and sedative effects under an acute stressful condition in chicks. However, no information is available on the effects of GSH on energy expenditure (EE) under stressful conditions. The purpose of the present study was to clarify whether i.c.v. injection of GSH affects EE of neonatal chicks, and whether EE is correlated with behavioral changes after isolation-induced stress. The EE was rapidly decreased by i.c.v. injection of GSH, but was increased 27 min after injection. This change in EE was correlated with behavioral changes in which GSH induced hypnotic and sedative effects shortly after injection, followed by a period in which activity increased. The present study demonstrates that central GSH initially causes lowered EE through hypnotic and sedative effects under an acute stressful condition in chicks.
最近，我们报道了脑室内（i.c.v.）注射还原型谷胱甘肽（GSH）可在雏鸡急性应激条件下诱导催眠和镇静作用。然而，目前尚无关于 GSH 在应激条件下对能量消耗（EE）影响的信息。本研究的目的是阐明脑室内注射 GSH 是否会影响新生雏鸡的 EE，以及 EE 是否与隔离诱导应激后的行为变化相关。脑室内注射 GSH 可迅速降低 EE，但在注射后 27 分钟增加。这种 EE 的变化与行为变化相关，即 GSH 在注射后不久诱导催眠和镇静作用，随后活动增加。本研究表明，中枢 GSH 在雏鸡急性应激条件下最初通过催眠和镇静作用导致 EE 降低。
