National Livestock Breeding Center, Odakura, Nishigo, Fukushima, Japan.
Anim Sci J. 2010 Feb;81(1):28-33. doi: 10.1111/j.1740-0929.2009.00713.x.
Leg weakness in pigs is a serious problem in the pig industry. We performed a whole genome quantitative trait locus (QTL) analysis to find QTLs affecting leg weakness traits in the Landrace population. Half-sib progeny (n = 522) with five sires were measured for leg weakness traits. Whole genome QTL mapping was performed using a half-sib regression-based method using 190 microsatellite markers. No experiment-wide significant QTLs affecting leg weakness traits were detected. However, at the 5% chromosome-wide level, QTLs affecting leg weakness traits were detected on chromosomes 1, 3, 10 and 11 with QTL effects ranging from 0.07 to 0.11 of the phenotypic variance. At the 1% chromosome-wide level, QTLs affecting rear feet score and total leg score were detected on chromosomes 2 and 3 with QTL effects of 0.11 and 0.13 of the phenotypic variance, respectively. On chromosome 3 and 10, some QTLs found in this study were located at nearby positions. The present study is one of the first reports of QTLs affecting fitness related traits such as leg weakness traits, that segregate within the Landrace population. The study also provides useful information for studying QTLs in purebred populations.
猪的腿部无力是养猪业的一个严重问题。我们进行了全基因组数量性状基因座（QTL）分析，以寻找影响长白猪种群腿部无力性状的 QTL。使用五个父本的半同胞后代（n=522）测量了腿部无力性状。使用基于半同胞回归的方法，使用 190 个微卫星标记进行了全基因组 QTL 作图。未检测到影响腿部无力性状的全实验显著 QTL。然而，在 5%的染色体-wide 水平上，在第 1、3、10 和 11 号染色体上检测到影响腿部无力性状的 QTL，QTL 效应范围为表型方差的 0.07 到 0.11。在 1%的染色体-wide 水平上，在第 2 和 3 号染色体上检测到影响后腿评分和总腿部评分的 QTL，QTL 效应分别为表型方差的 0.11 和 0.13。在第 3 和 10 号染色体上，本研究发现的一些 QTL 位于附近位置。本研究是第一个报道影响长白猪种群内分离的与健康相关性状（如腿部无力性状）的 QTL 的研究之一。该研究还为研究纯种群体中的 QTL 提供了有用的信息。
