Dar-Odeh Najla S, Hayajneh Wail A, Abu-Hammad Osama A, Hammad Huda M, Al-Wahadneh Adel M, Bulos Najwa K, Mahafzah Azmi M, Shomaf Maha S, El-Maaytah Mohammed A, Bakri Faris G
Faculty of Dentistry, University of Jordan, Amman, Jordan.
BMC Res Notes. 2010 Feb 17;3:37. doi: 10.1186/1756-0500-3-37.
Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients.
The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic non-specific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient.
Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage.
慢性肉芽肿病是一种极为罕见的原发性免疫缺陷综合征，可伴有多种口腔并发症。这会影响大量患者。然而，关于口腔并发症的数据却很稀少。在此，我们将回顾相关文献，并描述12例患者的口面部表现。
年龄范围为5至31岁。口腔表现各异，反映出口腔卫生水平较低。这些表现包括牙周炎、猖獗龋、牙龈炎、口疮样溃疡和地图舌。1例患者颊黏膜出现类似扁平苔藓的白色斑块。另1例患者舌背有结节，伴有裂纹舌和地图舌。后两个病变的活检显示为慢性非特异性黏膜炎。全景X线片显示1例患者有广泛的牙周炎，另1例患者有根尖周病变。
慢性肉芽肿病患者可能会出现反映其对感染和炎症易感性的口腔病变。社会和遗传因素也有可能影响这种并发症的发生。因此，必须将口腔卫生保持在最佳水平，以预防难以控制的感染。
