2nd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Psychiatry Res. 2010 May 15;177(1-2):156-60. doi: 10.1016/j.psychres.2010.01.006. Epub 2010 Feb 16.
The present study examined whether the comorbidity of obsessive-compulsive personality disorder (OCPD) and obsessive-compulsive disorder (OCD) constitute a specific subtype of OCD. The study sample consisted of 146 consecutive outpatients with a DSM-IV diagnosis of OCD. Diagnoses were established using MINI, IPDE, YBOCS and YBOCS-SC. OCD patients with comorbid OCPD were compared with OCD patients without OCPD on various sociodemographic and clinical variables. Almost one third of the OCD subjects met criteria for comorbid OCPD. OCD+OCPD patients had a significantly earlier age at onset of initial OC symptoms, earlier age at onset of OCD and more obsessions and compulsions than pure obsessions compared to the patients with OCDOCPD. OCD+OCPD patients also had a higher rate of comorbidity with avoidant personality disorder and showed more impairment in global functioning. There were not differences between the two sub-groups on severity of OCD symptoms and also on type of OCD onset. Our results indicate that the comorbidity of OCD with OCPD is associated with a number of specific clinical characteristics of OCD. These findings in conjunction with of current clinical, family and genetic studies provide some initial evidence that OCD comorbid with OCPD constitute a specific subtype of OCD.
本研究旨在探讨强迫症伴强迫人格障碍(OCPD)是否构成特定的强迫症亚型。研究样本包括 146 例 DSM-IV 强迫症门诊患者。采用 MINI、IPDE、YBOCS 和 YBOCS-SC 进行诊断。将伴 OCPD 的强迫症患者与不伴 OCPD 的强迫症患者在各种社会人口学和临床变量方面进行比较。将近三分之一的强迫症患者符合伴 OCPD 的标准。与仅有强迫症的患者相比,OCD+OCPD 患者的初始 OC 症状发病年龄更早,强迫症发病年龄更早,强迫观念和强迫行为更多。OCD+OCPD 患者还伴有回避型人格障碍的发病率更高,总体功能损害更大。在 OCD 症状严重程度和 OCD 发病类型上,两组之间没有差异。我们的研究结果表明,强迫症伴强迫人格障碍与强迫症的一些特定临床特征有关。这些发现与当前的临床、家庭和遗传研究一起,为强迫症伴强迫人格障碍构成特定的强迫症亚型提供了一些初步证据。