Ojdana Dominika, Safiejko Kamil, Milewski Robert, Sacha Paweł, Wieczorek Piotr, Lipska Alina, Radziwon Piotr, Dadan Jacek, Tryniszewska Elzbieta
Department of Microbiological Diagnostics, Medical University of Bialystok, Poland.
Folia Histochem Cytobiol. 2009 Jan;47(3):471-7. doi: 10.2478/v10042-009-0081-4.
More and more is known about the role of venous wall abnormalities and valvular incompetence in the development of chronic venous disorders (CVD). Unfortunately detailed mechanisms of CVD pathophysiology are not well understood. Recent studies focus on involvement of the inflammatory process in the structural remodeling of venous valves and venous wall. The aim of this study is to investigate and to document the memory T cells homeostasis in CVD patients. In this study we present lymphocytic changes in blood from varicose veins in terms of total CD4+ and CD8+ T cells and their particular subsets of memory T cells: TN, TCM and TEM. Results suggest that immunological memory may be involved in the CVD development.
关于静脉壁异常和瓣膜功能不全在慢性静脉疾病（CVD）发展中的作用，人们了解得越来越多。不幸的是，CVD病理生理学的详细机制尚未得到很好的理解。最近的研究集中在炎症过程参与静脉瓣膜和静脉壁的结构重塑。本研究的目的是调查和记录CVD患者中记忆T细胞的稳态。在本研究中，我们从静脉曲张患者的血液中呈现淋巴细胞变化，涉及总CD4+和CD8+T细胞及其记忆T细胞的特定亚群：TN、TCM和TEM。结果表明，免疫记忆可能参与CVD的发展。
