Madej Paweł, Plewka Andrzej, Plewka Danuta, Paleń Piotr, Nowaczyk Grazyna, Bogunia Edyta, Marczyński Jacek, Waloszek Józef
Departament of Gynaecological Endocrinology, Medical University of Silesia, 40-752 Katowice, Poland.
Folia Histochem Cytobiol. 2009 Jan;47(3):497-504. doi: 10.2478/v10042-009-0105-0.
Uterine myomas represent one of the most common female pathologies. Uterine smooth muscle myomas or fibromas are benign tumours which respond to hormones and their etiology induces wide interest. The myomas were found to contain aromatase and, in addition, cells of the myomas were found to synthesize estrogen. This study was conducted on patients with the myomas, in either generative age or in the perimenopausal period. Expression of aromatase was detected in patients of various age, with large or small uterine myomas, using an immunohistochemical technique. In addition expression of the enzyme was examined at the periphery of every myoma.
子宫肌瘤是最常见的女性疾病之一。子宫平滑肌肌瘤或纤维瘤是对激素有反应的良性肿瘤，其病因引起了广泛关注。研究发现肌瘤中含有芳香化酶，此外，还发现肌瘤细胞能合成雌激素。本研究针对处于生育年龄或围绝经期的子宫肌瘤患者开展。采用免疫组织化学技术，在不同年龄、患有大小不同子宫肌瘤的患者中检测芳香化酶的表达。此外，还在每个肌瘤的周边检查了该酶的表达。
