Plewka Danuta, Morek Michał, Bogunia Edyta, Waloszek Józef, Plewka Andrzej
Ginekol Pol. 2016;87(3):166-77. doi: 10.17772/gp/60979.
The aim of the study was to determine the expression of VEGF (vascular endothelial growth factor) isoforms and their receptors in uterine myomas.
The study included 40 women with myomas of reproductive age and 40 perimenopausal women (the study group). Myometrial samples (the control group) were taken from 10 women undergoing hysterectomy for ovarian tumors and 10 older women undergoing hysterectomy for uterine prolapse.
A significantly increased expression of VEGF-A has been found in myomas, both small and large, in the younger women, which may by a sign of increased angiogenesis and intensive tumor growth. In perimenopausal women, the increase of VEGF expression was observed only in the endothelium and vascular smooth muscle.
An important conclusion of this study is that angiogenesis is independent of myoma size, which may suggest intensive tumor growth and the related increased angiogenesis. High expression of VEGF-A and VEGF-R1 receptors in large myomas can probably cause malignant transformation and more extensive growth, regardless of patient age.
本研究旨在确定血管内皮生长因子（VEGF）亚型及其受体在子宫肌瘤中的表达情况。
本研究纳入了40名育龄期子宫肌瘤女性和40名围绝经期女性（研究组）。肌层样本（对照组）取自10名因卵巢肿瘤行子宫切除术的女性以及10名因子宫脱垂行子宫切除术的老年女性。
在年轻女性的子宫肌瘤中，无论大小，均发现VEGF - A的表达显著增加，这可能是血管生成增加和肿瘤生长活跃的迹象。在围绝经期女性中，仅在内皮细胞和血管平滑肌中观察到VEGF表达增加。
本研究的一个重要结论是，血管生成与肌瘤大小无关，这可能提示肿瘤生长活跃以及相关的血管生成增加。无论患者年龄如何，大肌瘤中VEGF - A和VEGF - R1受体的高表达可能会导致恶性转化和更广泛的生长。
