正常大鼠肝细胞中脂蛋白颗粒的位点。
Sites of lipoprotein particles in normal rat hepatocytes.
作者信息
Novikoff P M, Yam A
出版信息
J Cell Biol. 1978 Jan;76(1):1-11. doi: 10.1083/jcb.76.1.1.
Abstract
Very low density lipoprotein (VLDL) particles are packaged by the Golgi apparatus into vacuoles which move to the plasma membrane and empty the particles into the space of Disse, via exocytosis. Traditionally, all lipoprotein-containing cisternae and vacuoles are thought to be parts of this pathway. Observations reported here demonstrate that there is a second population of lipoprotein-containing cisternae and vacuoles. This population is part of GERL, an organelle we consider to be a specialized hydrolase-rich region of the endoplasmic reticulum (ER). To our knowledge, this is the first systematic study of GERL in normal rat hepatocytes.
摘要
极低密度脂蛋白（VLDL）颗粒由高尔基体包装成液泡，这些液泡移动到质膜，并通过胞吐作用将颗粒排空到狄氏间隙。传统上，所有含脂蛋白的池和液泡都被认为是该途径的一部分。本文报道的观察结果表明，存在第二批含脂蛋白的池和液泡。这群结构是GERL的一部分，GERL是一种细胞器，我们认为它是内质网（ER）中富含水解酶的特殊区域。据我们所知，这是对正常大鼠肝细胞中GERL的首次系统研究。
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