Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT, UK.
Cancer Biomark. 2010;6(1):21-32. doi: 10.3233/CBM-2009-0116.
Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) combined with conventional MRI can provide a whole body assessment of metastatic bone disease, improved lesion detection compared to other imaging techniques and a direct quantitative assessment of treatment response. In bone marrow, the presence of fat and bone trabeculae and their changing contributions with disease progression and response to treatment present unique challenges for data acquisition and image interpretation. This article discusses these challenges and reviews the potential of DW-MRI to provide a biomarker of response in metastatic bone disease.
弥散加权磁共振成像（DW-MRI）结合常规 MRI 可对转移性骨疾病进行全身评估，与其他成像技术相比，可提高病变检出率，并可直接定量评估治疗反应。在骨髓中，脂肪和骨小梁的存在及其随疾病进展和治疗反应的变化对数据采集和图像解读提出了独特的挑战。本文讨论了这些挑战，并综述了 DW-MRI 在转移性骨疾病中提供反应生物标志物的潜力。
