Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Surrey, SM2 5PT, UK.
Eur Radiol. 2011 Aug;21(8):1713-8. doi: 10.1007/s00330-011-2116-4. Epub 2011 Apr 7.
To establish normal bone marrow values of apparent diffusion coefficient (ADC) over an age range, compare them with metastatic and myelomatous involvement, to establish reproducibility and to optimise b values.
The ADCs of bone marrow in 7 volunteers (mean age 29.7 years), 34 volunteers (mean age 63.3 years) and 43 patients with metastatic and myelomatous involvement (mean age 65.5 years) were measured. In 9 volunteers diffusion weighted MRI was repeated within 7 days. b values were derived to optimise contrast between normal and pathological marrow.
The mean ADC of bone marrow in younger volunteers was significantly higher than that of older volunteers. The coefficient of reproducibility was 14.8%. The ADC mean of metastatic and myeloma bone disease was 1054 + / -456 x 10⁻⁶mm²s⁻¹. An ADC threshold of 655 × 10(-6) mm(2)s(-1) separated normal and abnormal marrow with a sensitivity and specificity of 90% and 93% respectively. Contrast between normal and abnormal marrow was optimal at b = 1389 smm(-2).
The reproducibility of ADC measurements in bone is equivalent to published data for soft tissue with a high sensitivity and specificity for separating abnormal from age matched normal bone marrow. A b value of around 1,400 smm(-2) is optimal for imaging bone marrow.
建立表观扩散系数（ADC）在年龄范围内的正常骨髓值，将其与转移性和骨髓瘤性受累进行比较，以确定可重复性并优化 b 值。
测量了 7 名志愿者（平均年龄 29.7 岁）、34 名志愿者（平均年龄 63.3 岁）和 43 名转移性和骨髓瘤性受累患者（平均年龄 65.5 岁）的骨髓 ADC 值。在 9 名志愿者中，在 7 天内重复进行了扩散加权 MRI。得出了 b 值以优化正常和病理性骨髓之间的对比度。
年轻志愿者的骨髓 ADC 平均值明显高于年长志愿者。可重复性系数为 14.8%。转移性和骨髓瘤性骨病的 ADC 平均值为 1054±456×10⁻⁶mm²s⁻¹。ADC 阈值为 655×10⁻⁶mm²s⁻¹，可将正常和异常骨髓分开，其敏感性和特异性分别为 90%和 93%。b 值为 1389 smm⁻²时，正常和异常骨髓之间的对比度最佳。
骨 ADC 测量的可重复性与软组织的已发表数据相当，具有很高的敏感性和特异性，可将异常与年龄匹配的正常骨髓分开。b 值约为 1400 smm⁻²时，对骨髓成像最佳。
