Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Cancer J. 2010 Jan-Feb;16(1):17-22. doi: 10.1097/PPO.0b013e3181d3eef5.
Triple-negative breast cancer is more likely to affect younger premenopausal women and despite being responsive to traditional chemotherapy, continues to carry a poor overall prognosis. Traditional protective factors for breast cancer such as multiparity and early primaparity actually increase the risk for the triple-negative variant. Unlike other breast cancers, the incidence of this disease is also much higher in African American and West African women. Among those with triple-negative disease in the United States, the mortality rates are also highest in African American women. Variations in risk factors and socioeconomic status, lack of treatment, delays in treatment, and inadequate dosing of chemotherapy are just a few of the many reasons that may explain why this incidence and survival disparity persists.
三阴性乳腺癌更可能影响年轻的绝经前女性，尽管对传统化疗有反应，但总体预后仍然较差。乳腺癌的传统保护因素，如多产和初产年龄早，实际上增加了三阴性乳腺癌的风险。与其他乳腺癌不同，这种疾病在美国非洲裔美国人和西非妇女中的发病率也高得多。在美国患有三阴性疾病的人群中，非洲裔美国女性的死亡率也是最高的。风险因素和社会经济地位的差异、治疗的缺乏、治疗的延迟以及化疗剂量不足等只是导致这种发病率和存活率差异持续存在的众多原因中的一部分。
