Starlard-Davenport Athena, Glover-Collins Katherine, Mahkoul Issam, Hutchins Laura, Westbrook Kent, Korourian Soheila, Enoch Kimberly, Preston Michael, Jackson Shakia N, Klimberg V Suzanne, Henry-Tillman Ronda
Department of Cancer Control and Population Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA.
Division of Breast Surgical Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA.
Springerplus. 2013 Oct 7;2:516. doi: 10.1186/2193-1801-2-516. eCollection 2013.
The purpose of this study was to determine if race is a factor on overall survival when stage at diagnosis is compared. In this study, a total of 93 women with triple negative breast cancer (TNBC) were evaluated for survival outcomes after diagnosis between the year 2000 through 2010. Thirty-five patients (38%) were African American (AA), and 58 patients (62%) were Caucasian. Overall survival rates were estimated using the Kaplan-Meier method and compared between groups using the log-rank test. Student's t-test was used to calculate differences in cancer recurrence and mortality rates by stage and race. Cox proportional hazards ratios were used to determine the association of patient and variables with clinical outcome. Of women diagnosed with stage 1 breast cancer, the overall survival rates for AAs was 100% compared to Caucasians at 94% (95% CI, 0.003 to 19; P = 0.5). For women with stage 2 breast cancer, overall survival for AA women was 85% and for Caucasian women was 86% (HR = 0.8; 95% CI, 0.3 to 2.6; P = 0.73). For advanced stages (stage 3 and 4), survival for AA women were 78% and 40% for Caucasian women (HR = 0.6; 95% CI 0.2 to 1.98; P = 0.43). Rates of recurrence and mortality were not significantly different between AA and Caucasian TNBC patients. After controlling for patient variables, race was not significantly associated with OS (HR = 1.24; 95% CI, 0.32 to 5.08; P = 0.74) when comparing AA to Caucasian patients. Our study suggests that race does not have an effect on overall survival in African American and Caucasian women diagnosed with TNBC in Arkansas.
本研究的目的是确定在比较诊断分期时，种族是否是影响总生存期的一个因素。在本研究中，对2000年至2010年间诊断出的93例三阴性乳腺癌（TNBC）女性患者的生存结果进行了评估。35例患者（38%）为非裔美国人（AA），58例患者（62%）为白种人。采用Kaplan-Meier方法估计总生存率，并使用对数秩检验在组间进行比较。采用学生t检验计算癌症复发率和死亡率在分期和种族方面的差异。使用Cox比例风险比来确定患者和变量与临床结局之间的关联。在诊断为1期乳腺癌的女性中，非裔美国人的总生存率为100%，而白种人为94%（95%CI，0.003至19；P = 0.5）。对于2期乳腺癌女性，非裔美国女性的总生存率为85%，白种女性为86%（HR = 0.8；95%CI，0.3至2.6；P = 0.73）。对于晚期（3期和4期），非裔美国女性的生存率为78%，白种女性为40%（HR = 0.6；95%CI 0.2至1.98；P = 0.43）。非裔美国人和白种TNBC患者之间的复发率和死亡率没有显著差异。在控制患者变量后，比较非裔美国人和白种人患者时，种族与总生存期没有显著关联（HR = 1.24；95%CI，0.32至5.08；P = 0.74）。我们的研究表明，种族对阿肯色州诊断为TNBC的非裔美国人和白种女性的总生存期没有影响。
