Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, La Jolla, California, USA.
Clin Pharmacol Ther. 2010 Apr;87(4):421-5. doi: 10.1038/clpt.2009.306. Epub 2010 Feb 17.
Several reports have demonstrated that the efficacy of latanoprost is influenced by the time of dosing. This model-based meta-analysis validates previous findings that evening dosing is superior to morning dosing and predicts the optimal time for dosing, based on the quantitative assessment of baseline and latanoprost-treated 24-h circadian intraocular pressure (IOP) curves. The results confirm the importance of the time of dosing as a factor that influences the extent of reduction in IOP and underline the need to take this factor into consideration in the design of glaucoma trials and therapy.
已有多项报告表明，拉坦前列素的疗效受到给药时间的影响。本基于模型的荟萃分析验证了先前的发现，即晚间给药优于晨间给药，并根据对基线和拉坦前列素治疗的 24 小时昼夜眼压（IOP）曲线的定量评估，预测了最佳的给药时间。这些结果证实了给药时间作为影响眼压降低程度的因素的重要性，并强调了在青光眼试验和治疗设计中需要考虑这一因素。
