Department of Immunology, Medical University of Gdańsk, Gdańsk, Poland.
J Hum Hypertens. 2010 Nov;24(11):755-62. doi: 10.1038/jhh.2010.7. Epub 2010 Feb 18.
The aim of the study was to analyse the relationship between the serum level of vascular endothelial growth factor (VEGF) and the incidence of hypertension (HT) in children and adolescents with type I diabetes mellitus (T1DM). One hundred and five patients with T1DM were enrolled in the study. The control group consisted of 30 healthy controls. All the T1DM patients were subjected to biochemical analyses, ophthalmologic examination and 24-h blood pressure monitoring. Besides, all the patients and healthy controls had serum VEGF levels measured with the use of the ELISA methodology. The essence of our research is that patients with T1DM and HT and with microalbuminuria (MA) and diabetic retinopathy (DR) (MA/DR) are characterized by a significantly higher level of VEGF (340.23±93.22 pg ml(-1)) in blood serum in comparison with the group of T1DM patients without HT and MA/DR (183.6±96.6 pg ml(-1)) and with healthy controls (145.32±75.58 pg ml(-1)). In addition, the VEGF level was significantly higher in T1DM patients, who presented all three complications, that is HT, retinopathy and MA in comparison with T1DM patients without HT, but with MA/DR (P=0.036). On the other hand, no statistically significant differences (P=0.19) were noted in the level of VEGF in serum between T1DM patients without HT and MA/DR and the healthy control group. At a further stage of analysis, using the method of multiple regression, it was shown that systolic pressure, HbA1c and duration of disease are independent factors influencing the concentration of VEGF. Summarizing, the measurement of VEGF serum levels allows for the identification of groups of patients who have the highest risk of HT and, subsequently, progression of vascular complications.
本研究旨在分析血管内皮生长因子（VEGF）血清水平与 1 型糖尿病（T1DM）儿童和青少年高血压（HT）发病之间的关系。研究纳入了 105 例 T1DM 患者。对照组由 30 名健康对照者组成。所有 T1DM 患者均进行了生化分析、眼科检查和 24 小时血压监测。此外，所有患者和健康对照者均采用 ELISA 法检测血清 VEGF 水平。我们的研究实质在于，患有 HT 及微量白蛋白尿（MA）和糖尿病视网膜病变（DR）（MA/DR）的 T1DM 患者，其血清 VEGF 水平（340.23±93.22pg/ml）明显高于无 HT 及 MA/DR 的 T1DM 患者（183.6±96.6pg/ml）和健康对照者（145.32±75.58pg/ml）。此外，与无 HT 但伴有 MA/DR 的 T1DM 患者相比，同时伴有 HT、视网膜病变和 MA 的 T1DM 患者的 VEGF 水平明显更高（P=0.036）。另一方面，无 HT 但伴有 MA/DR 的 T1DM 患者与健康对照者之间的血清 VEGF 水平差异无统计学意义（P=0.19）。在进一步的分析中，采用多元回归分析方法，结果表明收缩压、HbA1c 和病程是影响 VEGF 浓度的独立因素。综上所述，VEGF 血清水平的测量可识别 HT 风险最高的患者群体，进而识别血管并发症进展的风险。
