National Institute for Public Health Surveillance, Saint-Maurice, France.
J Med Virol. 2010 Apr;82(4):546-55. doi: 10.1002/jmv.21734.
To monitor the prevalence of hepatitis B and hepatitis C a cross-sectional survey was conducted in 2004 among French metropolitan residents. A complex sampling design was used to enroll 14,416 adult participants aged 18-80 years. Data collected included demographic and social characteristics and risk factors. Sera were tested for anti-HCV, HCV-RNA, anti-HBc and HBsAg. Data were analyzed with SUDAAN software to provide weighted estimates for the French metropolitan resident population. The overall anti-HCV prevalence was 0.84% (95% CI: 0.65-1.10). Among anti-HCV positive individuals, 57.4% (95% CI: 43.2-70.5) knew their status. Factors associated independently with positive anti-HCV were drug use (intravenous and nasal), blood transfusion before 1992, a history of tattoos, low socioeconomic status, being born in a country where anti-HCV prevalence >2.5%, and age >29 years. The overall anti-HBc prevalence was 7.3% (95%: 6.5-8.2). Independent risk factors for anti-HBc were intravenous drug use, being a man who has sex with men, low socioeconomic status, a stay in a psychiatric facility or facility for the mentally disabled, <12 years of education, being born in a country where HBsAg prevalence >2%, age >29 and male sex. The HCV RNA and HBsAg prevalence were 0.53% (95% CI: 0.40-0.70) and 0.65% (95% CI: 0.45-0.93), respectively. Among HBsAg positive individuals, 44.8% (95% CI: 22.8-69.1) knew their status. Anti-HCV prevalence was close to the 1990s estimates whereas HBsAg prevalence estimate was greater than expected. Screening of hepatitis B and C should be strengthened and should account for social vulnerability.
为了监测乙型肝炎和丙型肝炎的流行情况，2004 年在法国大都市居民中进行了一项横断面调查。采用复杂抽样设计，招募了 14416 名年龄在 18-80 岁的成年参与者。收集的数据包括人口统计学和社会特征以及危险因素。检测血清中的抗 HCV、HCV-RNA、抗 HBc 和 HBsAg。使用 SUDAAN 软件对数据进行分析，为法国大都市居民人口提供加权估计值。总的抗 HCV 流行率为 0.84%（95%CI：0.65-1.10）。在抗 HCV 阳性个体中，57.4%（95%CI：43.2-70.5）知道自己的状况。与抗 HCV 阳性独立相关的因素是药物使用（静脉和鼻内）、1992 年以前的输血、纹身史、低社会经济地位、出生在抗 HCV 流行率>2.5%的国家，以及年龄>29 岁。总的抗 HBc 流行率为 7.3%（95%：6.5-8.2）。抗 HBc 的独立危险因素是静脉药物使用、男男性行为者、低社会经济地位、精神科或精神障碍机构的停留、<12 年的教育、出生在 HBsAg 流行率>2%的国家、年龄>29 岁和男性。HCV RNA 和 HBsAg 的流行率分别为 0.53%（95%CI：0.40-0.70）和 0.65%（95%CI：0.45-0.93）。在 HBsAg 阳性个体中，44.8%（95%CI：22.8-69.1）知道自己的状况。抗 HCV 的流行率接近 20 世纪 90 年代的估计值，而 HBsAg 的流行率估计值高于预期。乙型肝炎和丙型肝炎的筛查应得到加强，并应考虑到社会脆弱性。
