Nzechieu Evenge Claudia Noumbissie, Zeuko'o Menkem Elisabeth, Ngounou Eleonore, Watching Djakissam, Nembu Erastus Nembo, Luma Woquan Sama, Seukep Armel Jackson, Bomba Taksinkou Francis Desire, Boyom Fabrice Fekam
Department of Biomedical Sciences, University of Buea, Cameroon.
Antimicrobial and Biocontrol Agent Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaoundé 1, Cameroon.
Heliyon. 2023 Jul 4;9(7):e17745. doi: 10.1016/j.heliyon.2023.e17745. eCollection 2023 Jul.
Hepatitis B infection is a serious global health problem worldwide. In Cameroon, this infection shows a great variability in prevalence in the country and even within different population groups. However, the prevalence of HBV in the southwestern region is not yet known.
This study was conducted to determine the prevalence of hepatitis B, its associated factors, and the patient's knowledge about the infection at the Buea Regional Hospital.
We conducted a hospital-based cross-sectional study from March 29th to June 30th, 2021 involving participants of both sexes with ages ranging from 13 to 60+. A random sampling method was used to obtain a sample size of 113 participants as calculated using Lorentz's formula. The study questionnaires were administered to participants and their blood samples were collected by venous puncture. The blood samples were collected in non-hepainized test tube at the collection units of the Hospital. Diaspot one-step Hepatitis B Surface Antigen test strips with 99% sensitivity and 97% specificity were used to determine the status of the participants. The data were analysed using SPSS 25.0. Bivariate and multivariable analyses were used to obtain associated factors. The level of significance was set at p ≤ 0.05.
A total of 125 participants were recruited. However, only 119 provided complete data (questionnaire and blood samples). A proportion 61 (51.3%) of the participants were females in the 20-29-year age group. The prevalence of hepatitis was 8.4%. Fifty-three percent (64) of the participants had adequate knowledge of Hepatitis B. Having had more than one sexual partner in the last six months and having visited a dentist in the past was significantly associated with Hepatitis B positive status (p ≤ 0.05).
The prevalence of Hepatitis B in the Buea Regional Hospital is 8.4% and 53.8% of the participants had adequate knowledge of the infection. Males were found to be 13.17 times more likely to be positive for Hepatitis B infection than females.
乙型肝炎感染是全球严重的公共卫生问题。在喀麦隆，这种感染在该国乃至不同人群中的患病率差异很大。然而，西南地区的乙肝病毒（HBV）患病率尚不清楚。
本研究旨在确定布埃亚地区医院乙型肝炎的患病率、相关因素以及患者对该感染的认知情况。
我们于2021年3月29日至6月30日进行了一项基于医院的横断面研究，研究对象为年龄在13岁至60岁以上的男女参与者。采用随机抽样方法，根据洛伦兹公式计算得出样本量为113名参与者。向参与者发放研究问卷，并通过静脉穿刺采集他们的血样。血样在医院采集单元的未加肝素的试管中收集。使用灵敏度为99%、特异性为97%的Diaspot一步法乙型肝炎表面抗原检测试纸来确定参与者的感染状况。数据使用SPSS 25.0进行分析。采用双变量和多变量分析来获取相关因素。显著性水平设定为p≤0.05。
共招募了125名参与者。然而，只有119人提供了完整数据（问卷和血样）。20至29岁年龄组中61名（51.3%）参与者为女性。肝炎患病率为8.4%。53%（64名）的参与者对乙型肝炎有足够的了解。在过去六个月内有多个性伴侣以及过去看过牙医与乙型肝炎阳性状态显著相关（p≤0.05）。
布埃亚地区医院的乙型肝炎患病率为8.4%，53.8%的参与者对该感染有足够的了解。发现男性感染乙型肝炎呈阳性的可能性是女性的13.17倍。
