Z-选择性铜催化的不对称烯丙基烷基化与格氏试剂。
Z-Selective copper-catalyzed asymmetric allylic alkylation with Grignard reagents.
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
出版信息
J Am Chem Soc. 2012 Mar 7;134(9):4108-11. doi: 10.1021/ja300743t. Epub 2012 Feb 27.
PMID:22352853
Abstract
Allylic gem-dichlorides undergo regio- and enanantioselective (er up to 99:1) copper-catalyzed allylic alkylation with Grignard reagents affording chiral Z-vinyl chlorides. This highly versatile class of synthons can be subjected to Suzuki cross coupling affording optically active Z-alkenes and 1,3-cis,trans dienes.
摘要
烯丙基偕二氯代物与格氏试剂进行区域和对映选择性（er 高达 99:1）铜催化的烯丙基烷基化反应，生成手性 Z-乙烯基氯。这种多功能的合成子可以进行 Suzuki 交叉偶联反应，得到光学活性的 Z-烯烃和 1,3-顺式，反式二烯。
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