Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Med Mycol. 2010 Nov;48(7):897-903. doi: 10.3109/13693781003621575.
The role of TLR4 in the recognition of Candida albicans has been brought into question. In order to assess whether discrepancies in the literature are due to differences in the recognition of various C. albicans strains, we selected 14 different isolates of C. albicans to evaluate their recognition by TLR4 and lectin receptors. We demonstrate that recognition of cell wall structures by lectin receptors is a consistent characteristic independent of the C. albicans strain selected, while recognition by TLR4 is a more variable feature. These data were corroborated by the increased susceptibility of TLR4-/- mice to a C. albicans strain recognized by TLR4, but not to a strain in which recognition has been shown to be independent of this receptor. This suggests a heavier reliance of in vivo antifungal host defense on lectin receptors than on TLRs, a notion compatible with the clinical picture in individuals deficient in MyD88/TLRs or dectin-1/CARD9.
TLR4 在识别白念珠菌中的作用受到质疑。为了评估文献中的差异是否是由于对不同白念珠菌菌株的识别不同所致，我们选择了 14 种不同的白念珠菌分离株来评估它们被 TLR4 和凝集素受体的识别。我们证明，凝集素受体对细胞壁结构的识别是一种独立于所选白念珠菌菌株的一致特征，而 TLR4 的识别则是一个更为多变的特征。这些数据得到了 TLR4-/- 小鼠对被 TLR4 识别的白念珠菌菌株的易感性增加的证实，但对已显示其识别不依赖于该受体的菌株则没有增加易感性。这表明，在体内抗真菌宿主防御中，凝集素受体比 TLR 更为重要，这一观点与 MyD88/TLR 或 dectin-1/CARD9 缺陷个体的临床特征相符。
