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分泌途径在发病机制中的作用。

The Role of Secretory Pathways in Pathogenesis.

作者信息

Rollenhagen Christiane, Mamtani Sahil, Ma Dakota, Dixit Reva, Eszterhas Susan, Lee Samuel A

机构信息

Medicine Service, White River Junction VA Medical Center, White River Junction, VT 05009, USA.

Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

出版信息

J Fungi (Basel). 2020 Feb 24;6(1):26. doi: 10.3390/jof6010026.

Abstract

is a fungus that is a commensal organism and a member of the normal human microbiota. It has the ability to transition into an opportunistic invasive pathogen. Attributes that support pathogenesis include secretion of virulence-associated proteins, hyphal formation, and biofilm formation. These processes are supported by secretion, as defined in the broad context of membrane trafficking. In this review, we examine the role of secretory pathways in virulence, with a focus on the model opportunistic fungal pathogen, .

摘要

是一种真菌,它是一种共生生物,也是正常人类微生物群的成员。它有能力转变为机会性侵袭性病原体。支持发病机制的属性包括毒力相关蛋白的分泌、菌丝形成和生物膜形成。这些过程由分泌来支持,如在膜运输的广泛背景下所定义的那样。在本综述中,我们研究分泌途径在毒力中的作用,重点关注模式机会性真菌病原体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b796/7151058/33c5c222ef2e/jof-06-00026-g001.jpg

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