Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, People's Republic of China.
Autoimmunity. 2010 Jun;43(4):264-74. doi: 10.3109/08916930903509049.
The tumor necrosis factor-alpha (TNF-alpha) promoter--238A/G polymorphism has been repeatedly associated with systemic lupus erythematosus (SLE), but findings are not consistent across studies. Our aim was to do a meta-analysis to assess the association between TNF-alpha promoter--238A/G polymorphism and SLE. Eleven published studies of this polymorphism with SLE in different ethnic groups were identified using a Medline search. Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG+GA, GA+AA versus GG, and A allele versus G allele in a fixed/random effect model. The overall odds ratio (OR) of the AA versus GG+GA genotypes was 3.46 (95% CI = 1.35-8.83, P = 0.01), and a similar result was found in Caucasian population (OR = 4.62, 95% CI = 1.20-17.80, P = 0.03); the overall OR of the AA versus GG genotypes was 3.36 (95% CI = 1.32-8.55, P = 0.01), and a similar result was found in Caucasian population (OR = 4.29, 95% CI = 1.11-16.53, P = 0.03); the OR of the GA versus GG genotypes was 0.48 (95% CI = 0.30-0.75, P = 0.001) in Caucasian population. In conclusion, this meta-analysis demonstrates the association between TNF-alpha promoter - 238A/G polymorphism and SLE, especially in Caucasian population.
肿瘤坏死因子-α（TNF-α）启动子-238A/G 多态性与系统性红斑狼疮（SLE）反复相关，但研究结果不一致。我们的目的是进行荟萃分析，以评估 TNF-α启动子-238A/G 多态性与 SLE 之间的关联。使用 Medline 搜索，确定了 11 项针对不同种族人群中 TNF-α启动子-238A/G 多态性与 SLE 的已发表研究。采用固定/随机效应模型对基因型 AA 与 GG、GA 与 GG、AA 与 GG+GA、GA+AA 与 GG 以及 A 等位基因与 G 等位基因进行荟萃分析。AA 与 GG+GA 基因型的总体比值比（OR）为 3.46（95%置信区间=1.35-8.83，P=0.01），在白种人群中也发现了类似的结果（OR=4.62，95%置信区间=1.20-17.80，P=0.03）；AA 与 GG 基因型的总体 OR 为 3.36（95%置信区间=1.32-8.55，P=0.01），在白种人群中也发现了类似的结果（OR=4.29，95%置信区间=1.11-16.53，P=0.03）；GA 与 GG 基因型的 OR 为 0.48（95%置信区间=0.30-0.75，P=0.001）在白种人群中。总之，这项荟萃分析表明 TNF-α启动子-238A/G 多态性与 SLE 之间存在关联，尤其是在白种人群中。
