Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China.
Rheumatol Int. 2011 Aug;31(8):1055-64. doi: 10.1007/s00296-010-1392-7. Epub 2010 Mar 24.
The aim of this study was to summarize results on the association of tumor necrosis factor-α (TNF-α) promoter -308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Asian populations by using the meta-analysis. We searched all the publications about the association between TNF-α promoter -308A/G polymorphism and SLE in Asian populations from PubMed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG + GA, GA + AA versus GG, and A allele versus G allele in a fixed/random effect model. A total of 12 studies (1017 cases and 1086 controls) were included in the current meta-analysis (Chinese, Japanese, and Thai). When all groups were pooled, a significant association of A allele and increased SLE risk was found (OR = 1.44, 95%CI = 1.04-2.01, P = 0.03). When analyses were restricted to more ethnically homogeneous populations, similar result was found in Chinese population (OR = 1.59, 95%CI = 1.12-2.26, P = 0.009). But the association between TNF-α promoter -308 polymorphism and SLE was not observed when examining the contrast of G/A + A/A versus G/G, A/A versus A/G + G/G, A/A versus G/G, and G/A versus G/G. This meta-analysis demonstrates the association between TNF-α promoter -308A/G polymorphism and SLE in Asian populations, especially in Chinese population.
本研究旨在通过荟萃分析总结肿瘤坏死因子-α（TNF-α）启动子-308A/G 多态性与亚洲人群系统性红斑狼疮（SLE）易感性的关联结果。我们从 PubMed、Elsevier Science Direct、中国生物医学文献数据库（CBM）、中国国家知识基础设施（CNKI）和万方（中国）检索了所有关于 TNF-α启动子-308A/G 多态性与亚洲人群 SLE 关联的出版物。采用固定/随机效应模型对基因型 AA 与 GG、GA 与 GG、AA 与 GG+GA、GA+AA 与 GG 以及 A 等位基因与 G 等位基因进行荟萃分析。本荟萃分析共纳入 12 项研究（1017 例病例和 1086 例对照）（中文、日文和泰文）。当所有组合并时，发现 A 等位基因与 SLE 风险增加存在显著关联（OR=1.44，95%CI=1.04-2.01，P=0.03）。当分析仅限于更为同质性的人群时，在中国人群中也发现了类似的结果（OR=1.59，95%CI=1.12-2.26，P=0.009）。但是，当检查 G/A+A/A 与 G/G、A/A 与 A/G+G/G、A/A 与 G/G 以及 G/A 与 G/G 时，未观察到 TNF-α 启动子-308 多态性与 SLE 之间存在关联。本荟萃分析表明 TNF-α 启动子-308A/G 多态性与亚洲人群，尤其是中国人群中的 SLE 存在关联。
