Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032 Hefei, Anhui, People's Republic of China.
Rheumatol Int. 2012 Jul;32(7):2083-92. doi: 10.1007/s00296-011-1924-9. Epub 2011 Apr 16.
Published data on the association between tumor necrosis factor-alpha (TNF-α) promoter-308 A/G polymorphism and systemic lupus erythematosus (SLE) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 28 studies including 2,992 cases and 4,326 controls (5,924 cases and 8,484 controls in A versus G comparison) were involved in this meta-analysis. Meta-analysis was performed for genotypes A/A (recessive effect), A/A+A/G (dominant effect), and A allele in fixed or random effects models. In addition, we also performed a "model-free" analysis by considering the G/G genotype as the reference and estimated the OR for the A/A versus G/G and A/G versus G/G genotype. Overall, an association of TNF-α promoter-308 A/G polymorphism with SLE was found (A versus G: OR = 1.686, 95% CI = 1.400-2.032, P < 0.001; A/A versus A/G+G/G: OR = 3.043, 95% CI = 2.185-4.238, P < 0.001; A/A+A/G versus G/G: OR = 1.822, 95% CI = 1.379-2.407, P < 0.001; A/A versus G/G: OR = 3.686, 95% CI = 2.628-5.172, P < 0.001; A/G versus G/G: OR = 1.691, 95% CI = 1.291-2.215, P < 0.001). However, stratification by ethnicity indicated that the risk A allele was not associated with SLE in Asian (A versus G: OR = 1.207, 95% CI = 0.856-1.702, P = 0.283) and African population (A versus G: OR = 1.225, 95% CI = 0.597-2.516, P = 0.580). In summary, this meta-analysis indicated that TNF-α promoter-308-A/G polymorphism is associated with susceptibility to SLE.
关于肿瘤坏死因子-α（TNF-α）启动子-308A/G 多态性与系统性红斑狼疮（SLE）风险之间的关联，已有发表的数据尚无定论。为了更准确地评估这种关系，进行了荟萃分析。这项荟萃分析共纳入了 28 项研究，包括 2992 例病例和 4326 例对照（A 与 G 比较时，5924 例病例和 8484 例对照）。采用固定或随机效应模型，对基因型 A/A（隐性效应）、A/A+A/G（显性效应）和 A 等位基因进行荟萃分析。此外，我们还通过将 G/G 基因型视为参考，考虑了“无模型”分析，并估计了 A/A 与 G/G 和 A/G 与 G/G 基因型的 OR。总体而言，TNF-α启动子-308A/G 多态性与 SLE 相关（A 与 G：OR=1.686，95%CI=1.400-2.032，P<0.001；A/A 与 A/G+G/G：OR=3.043，95%CI=2.185-4.238，P<0.001；A/A+A/G 与 G/G：OR=1.822，95%CI=1.379-2.407，P<0.001；A/A 与 G/G：OR=3.686，95%CI=2.628-5.172，P<0.001；A/G 与 G/G：OR=1.691，95%CI=1.291-2.215，P<0.001）。然而，按种族进行分层表明，亚洲人群（A 与 G：OR=1.207，95%CI=0.856-1.702，P=0.283）和非洲人群（A 与 G：OR=1.225，95%CI=0.597-2.516，P=0.580）中，风险 A 等位基因与 SLE 无关。总之，这项荟萃分析表明，TNF-α 启动子-308A/G 多态性与 SLE 的易感性相关。
