Laboratory of Cognitive Psychology and Neuroscience, Université Paris Descartes - CNRS (UMR 8189), France.
Brain Cogn. 2010 Apr;72(3):457-63. doi: 10.1016/j.bandc.2010.01.001. Epub 2010 Feb 18.
The neuropsychological literature on the processing of emotions in Parkinson's disease (PD) reveals conflicting evidence about the role of the basal ganglia in the recognition of facial emotions. Hence, the present study had two objectives. One was to determine the extent to which the visual processing of emotions and objects differs in PD. The other was to assess the impact of cognitive load on the processing of these types of information. Thirty-one patients with idiopathic PD (IPD) under dopamine replacement therapy (DRT) were compared to 30 control subjects on emotion and object recognition tasks. Recognition of objects was more accurate and faster than recognition of facial expressions of emotion, for both groups of subjects. In a second experiment using an N-back procedure with the same stimuli-a more demanding task with a higher cognitive load-patients with IPD were as accurate as control subjects in detecting the correct sequential presentation of stimuli, but were much slower in their decision responses. This indicates that IPD patients under DRT are not impaired in encoding emotion or object information, but that they have difficulty with the processing demands of the N-back task. Thus, patients with IPD appear to be more sensitive to cognitive load than to type of information, whether facial emotions or objects. In this perspective, one must consider that a deafferented dopaminergic system has problems processing more complex information before one can posit the existence of deficits affecting a specific type of information.
帕金森病（PD）患者情绪处理的神经心理学文献显示，基底神经节在面部情绪识别中的作用存在相互矛盾的证据。因此，本研究有两个目的。一个是确定帕金森病患者在情绪和物体的视觉处理上有何不同。另一个是评估认知负荷对这些类型信息处理的影响。将 31 名接受多巴胺替代疗法（DRT）的特发性帕金森病（IPD）患者与 30 名对照组在情绪和物体识别任务上进行比较。对于两组受试者来说，物体的识别比情绪面部表情的识别更准确和更快。在第二个实验中，使用相同的刺激进行 N-back 程序-一个具有更高认知负荷的更具挑战性的任务-IPD 患者在检测刺激的正确顺序呈现方面与对照组一样准确，但在决策反应方面要慢得多。这表明，DRT 下的 IPD 患者在编码情绪或物体信息方面没有受损，但在 N-back 任务的处理要求方面存在困难。因此，与信息类型（无论是面部情绪还是物体）相比，IPD 患者似乎对认知负荷更为敏感。从这个角度来看，在假设存在影响特定类型信息的缺陷之前，必须考虑到去神经多巴胺能系统在处理更复杂信息方面存在问题。
