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对帕金森病患者在进行情绪处理时的 EEG 功率、频率和不对称性进行分析。

On the analysis of EEG power, frequency and asymmetry in Parkinson's disease during emotion processing.

机构信息

School of Mechatronic Engineering, Universiti Malaysia Perlis (UniMAP), Arau, Malaysia.

出版信息

Behav Brain Funct. 2014 Apr 9;10:12. doi: 10.1186/1744-9081-10-12.

DOI:10.1186/1744-9081-10-12
PMID:24716619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4234023/
Abstract

OBJECTIVE

While Parkinson's disease (PD) has traditionally been described as a movement disorder, there is growing evidence of disruption in emotion information processing associated with the disease. The aim of this study was to investigate whether there are specific electroencephalographic (EEG) characteristics that discriminate PD patients and normal controls during emotion information processing.

METHOD

EEG recordings from 14 scalp sites were collected from 20 PD patients and 30 age-matched normal controls. Multimodal (audio-visual) stimuli were presented to evoke specific targeted emotional states such as happiness, sadness, fear, anger, surprise and disgust. Absolute and relative power, frequency and asymmetry measures derived from spectrally analyzed EEGs were subjected to repeated ANOVA measures for group comparisons as well as to discriminate function analysis to examine their utility as classification indices. In addition, subjective ratings were obtained for the used emotional stimuli.

RESULTS

Behaviorally, PD patients showed no impairments in emotion recognition as measured by subjective ratings. Compared with normal controls, PD patients evidenced smaller overall relative delta, theta, alpha and beta power, and at bilateral anterior regions smaller absolute theta, alpha, and beta power and higher mean total spectrum frequency across different emotional states. Inter-hemispheric theta, alpha, and beta power asymmetry index differences were noted, with controls exhibiting greater right than left hemisphere activation. Whereas intra-hemispheric alpha power asymmetry reduction was exhibited in patients bilaterally at all regions. Discriminant analysis correctly classified 95.0% of the patients and controls during emotional stimuli.

CONCLUSION

These distributed spectral powers in different frequency bands might provide meaningful information about emotional processing in PD patients.

摘要

目的

虽然帕金森病（PD）传统上被描述为一种运动障碍，但越来越多的证据表明，与该疾病相关的情绪信息处理存在中断。本研究旨在探讨在情绪信息处理过程中，是否存在可区分 PD 患者和正常对照的特定脑电图（EEG）特征。

方法

从 20 名 PD 患者和 30 名年龄匹配的正常对照中采集了 14 个头皮部位的 EEG 记录。使用多模态（视听）刺激来引发特定的目标情绪状态，如快乐、悲伤、恐惧、愤怒、惊讶和厌恶。从频谱分析的 EEG 中得出的绝对和相对功率、频率和不对称性测量值，经过组间重复方差分析以及判别函数分析，以检查其作为分类指标的效用。此外，还对所用情绪刺激进行了主观评分。

结果

行为上，PD 患者在情绪识别方面没有受损，这可以通过主观评分来衡量。与正常对照组相比，PD 患者的整体相对 delta、theta、alpha 和 beta 功率较小，双侧前区的绝对 theta、alpha 和 beta 功率较小，不同情绪状态下的平均总频谱频率较高。注意到了左右半球 theta、alpha 和 beta 功率的不对称指数差异，对照组表现出右半球比左半球更大的激活。而患者双侧所有区域的半球内 alpha 功率不对称性降低。判别分析正确分类了 95.0%的患者和对照组在情绪刺激期间的情况。

结论

这些不同频带的分布式光谱功率可能为 PD 患者的情绪处理提供有意义的信息。

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