Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Eur Cytokine Netw. 2009 Dec;20(4):220-4. doi: 10.1684/ecn.2009.0173.
Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors. A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is mostly extrinsic to the vasculature. Recently however, endothelial cells themselves have been found to produce angiogenesis inhibitors including delta-like 4 and vasohibin 1. These intrinsic factors are thought to regulate angiogenesis by an autoregulatory or negative-feedback mechanism. This review focuses on such negative regulators of angiogenesis produced by endothelial cells.
血管生成受血管生成刺激物和抑制剂之间的局部平衡调节。体内已经发现了许多内源性血管生成抑制剂。这些抑制剂的来源主要是血管系统以外的。然而，最近发现内皮细胞本身也会产生血管生成抑制剂，包括 delta-like 4 和 vasohibin 1。这些内在因素被认为通过自调节或负反馈机制来调节血管生成。本文主要综述内皮细胞产生的这种血管生成负调控因子。
