Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Sendai 980-8575, Japan.
Vascul Pharmacol. 2012 May-Jun;56(5-6):262-6. doi: 10.1016/j.vph.2012.01.002. Epub 2012 Jan 21.
Angiogenesis is thought to be regulated by the local balance between angiogenesis stimulators and angiogenesis inhibitors. A number of endogenous regulators of angiogenesis have been found in the body. We recently isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and VASH2 as a homologue of VASH1 thereafter. We found that VASH1 was expressed in endothelial cells to terminate angiogenesis, whereas VASH2 promoted angiogenesis, in the mouse model of angiogenesis. This mini-review will focus on the vasohibin family in relation to the regulation of angiogenesis.
血管生成被认为受到血管生成刺激物和抑制剂之间的局部平衡调节。体内已经发现了许多血管生成的内源性调节剂。我们最近分离出血管抑素-1（VASH1）作为内皮细胞产生的血管生成负反馈调节剂，此后又发现了 VASH2 是 VASH1 的同源物。我们发现 VASH1 在血管生成的小鼠模型中表达于内皮细胞以终止血管生成，而 VASH2 促进血管生成。这篇简要综述将重点介绍血管抑素家族与血管生成调节的关系。
