Kim Young Kwan, Moon Jeong Seop, Ryu Soo Hyung, Lee Jung Hwan, Kim You Sun
Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2010 Feb;55(2):109-18. doi: 10.4166/kjg.2010.55.2.109.
BACKGROUND/AIMS: The aim of this study was to investigate the frequency of heartburn produced by beverages available in Korea and to clarify the mechanism causing heartburn.
We measured pH, titratable acidity, and osmolality of 35 beverages in vitro and correlated them with the severity of heartburn reported by questionnaire in 382 patients from November 2004 to June 2005.
Coffee (1.15) and soju (1.12) showed the highest heartburn score, while oolong tea (0.17) and carrot juice (0.18) showed the lowest heartburn score among all beverages. Titratable acidity of citrus juices correlated with heartburn (r=0.78; p=0.023). Soft drinks had the lowest pH, which was unrelated with heartburn scores (r=-0.54; p=0.460). Increasing pH among alcoholic beverages was correlated with heartburn scores (r=0.84; p=0.037), and osmolality was inversely associated with heartburn scores (r=-0.86; p=0.028). The heartburn score of decaffeinated coffee was significantly lower than that of regular coffee (p<0.001). Regular milk caused more heartburn than low-fat milk (p=0.008).
Our findings provide dietary information that helps to select appropriate beverages to the patients with heartburn.
背景/目的:本研究旨在调查韩国市场上各类饮料引发胃灼热的频率,并阐明其引发胃灼热的机制。
我们在体外测量了35种饮料的pH值、可滴定酸度和渗透压,并将其与2004年11月至2005年6月期间382例患者通过问卷调查报告的胃灼热严重程度进行关联分析。
在所有饮料中,咖啡(1.15)和烧酒(1.12)的胃灼热评分最高,而乌龙茶(0.17)和胡萝卜汁(0.18)的胃灼热评分最低。柑橘汁的可滴定酸度与胃灼热相关(r = 0.78;p = 0.023)。软饮料的pH值最低,但与胃灼热评分无关(r = -0.54;p = 0.460)。酒精饮料中pH值的升高与胃灼热评分相关(r = 0.84;p = 0.037),而渗透压与胃灼热评分呈负相关(r = -0.86;p = 0.028)。脱咖啡因咖啡的胃灼热评分显著低于普通咖啡(p < 0.001)。全脂牛奶比低脂牛奶更容易引发胃灼热(p = 0.008)。
我们的研究结果提供了饮食方面的信息,有助于为胃灼热患者选择合适的饮料。