Lee Jung Eun, Hunter David J, Spiegelman Donna, Adami Hans-Olov, Bernstein Leslie, van den Brandt Piet A, Buring Julie E, Cho Eunyoung, English Dallas, Folsom Aaron R, Freudenheim Jo L, Gile Graham G, Giovannucci Edward, Horn-Ross Pamela L, Leitzmann Michael, Marshall James R, Männistö Satu, McCullough Marjorie L, Miller Anthony B, Parker Alexander S, Pietinen Pirjo, Rodriguez Carmen, Rohan Thomas E, Schatzkin Arthur, Schouten Leo J, Willett Walter C, Wolk Alicja, Zhang Shumin M, Smith-Warner Stephanie A
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Int J Cancer. 2007 Nov 15;121(10):2246-53. doi: 10.1002/ijc.22909.
Specific beverage intake may be associated with the risk of renal cell cancer through a diluting effect of carcinogens, alterations of hormone levels, or other changes in the renal tubular environment, but few prospective studies have examined these associations. We evaluated the associations between coffee, tea, milk, soda and fruit and vegetable juice intakes and renal cell cancer risk in a pooled analysis of 13 prospective studies (530,469 women and 244,483 men). Participants completed a validated food-frequency questionnaire at baseline. Using the primary data, the study-specific relative risks (RRs) were calculated and then pooled using a random effects model. A total of 1,478 incident renal cell cancer cases were identified during a follow-up of 7-20 years across studies. Coffee consumption was associated with a modestly lower risk of renal cell cancer (pooled multivariate RR for 3 or more 8 oz (237 ml) cups/day versus less than one 8 oz (237 ml) cup/day = 0.84; 95% CI = 0.67-1.05; p value, test for trend = 0.22). Tea consumption was also inversely associated with renal cell cancer risk (pooled multivariate RR for 1 or more 8 oz (237 ml) cups/day versus nondrinkers = 0.85; 95% CI = 0.71-1.02; pvalue, test for trend = 0.04). No clear associations were observed for milk, soda or juice. Our findings provide strong evidence that neither coffee nor tea consumption increases renal cell cancer risk. Instead, greater consumption of coffee and tea may be associated with a lower risk of renal cell cancer. (c) 2007 Wiley-Liss, Inc.
特定饮料的摄入可能通过致癌物的稀释作用、激素水平的改变或肾小管环境的其他变化与肾细胞癌风险相关，但很少有前瞻性研究探讨这些关联。我们在对13项前瞻性研究（530,469名女性和244,483名男性）的汇总分析中评估了咖啡、茶、牛奶、汽水和果蔬汁摄入量与肾细胞癌风险之间的关联。参与者在基线时完成了一份经过验证的食物频率问卷。利用原始数据，计算了各研究的特定相对风险（RRs），然后使用随机效应模型进行汇总。在各研究7至20年的随访期间，共确定了1478例肾细胞癌新发病例。咖啡消费与肾细胞癌风险适度降低相关（每天饮用3杯或更多8盎司（237毫升）咖啡与每天饮用少于1杯8盎司（237毫升）咖啡相比，汇总多变量RR = 0.84；95%CI = 0.67 - 1.05；p值，趋势检验 = 0.22）。茶的消费也与肾细胞癌风险呈负相关（每天饮用1杯或更多8盎司（237毫升）茶与不饮茶者相比，汇总多变量RR = 0.85；95%CI = 0.71 - 1.02；p值，趋势检验 = 0.04）。未观察到牛奶、汽水或果汁有明显关联。我们的研究结果提供了有力证据，表明饮用咖啡和茶均不会增加肾细胞癌风险。相反，更多地饮用咖啡和茶可能与较低的肾细胞癌风险相关。(c) 2007 Wiley - Liss, Inc.
