Yoo Ki Deok, Han Dong Soo, Chung Seong Min, Kim Sun Min, Bae Joong Ho, Eun Chang Soo, Paik Seung Sam, Oh Young-Ha
Departments of Internal Medicine and Pathology, Hanyang University College of Medicine, Guri, Korea.
Korean J Gastroenterol. 2010 Feb;55(2):127-32. doi: 10.4166/kjg.2010.55.2.127.
Histiocytic sarcoma is a rare malignant neoplasm that originates from a histiocytic hematopoietic lineage characterized by histiocytic differentiation and its corresponding immunophenotypic features. Patients with histiocytic sarcoma usually have a poor prognosis due to its aggressive clinical behavior. Here we report a rare case of extranodal histiocytic sarcoma of the stomach which was confirmed through immunohistochemical staining. A 71-year- old man was presented with epigastric pain. Gastroscopy, abdominal CT, and EUS revealed a mass located on the posterior wall of upper body and fundus of the stomach. Grossly, grayish white solid masses were seen extending down to the submucosal layer. Microscopically, the tumor cells had eosinophilic cytoplasm, abundant vacuole, and mitosis. Immunohistochemical staining revealed that the tumor cells were positive for LCA, CD68, and lysozyme. Early detection and accurate diagnosis of this rare neoplasm is important because it can make a great difference in prognostic outcomes. To make an accurate and definitive diagnosis, immunohistochemical staining is essential in the confirmation of histiocytic origin.
组织细胞肉瘤是一种罕见的恶性肿瘤，起源于具有组织细胞分化及其相应免疫表型特征的组织细胞造血谱系。由于其侵袭性的临床行为，组织细胞肉瘤患者的预后通常较差。在此，我们报告一例罕见的胃外生性组织细胞肉瘤，通过免疫组织化学染色得以确诊。一名71岁男性出现上腹部疼痛。胃镜检查、腹部CT和超声内镜检查显示胃体上部和胃底后壁有一肿块。大体上，可见灰白色实性肿块延伸至黏膜下层。显微镜下，肿瘤细胞具有嗜酸性细胞质、丰富的空泡和有丝分裂。免疫组织化学染色显示肿瘤细胞LCA、CD68和溶菌酶呈阳性。早期发现和准确诊断这种罕见肿瘤很重要，因为这对预后结果有很大影响。为了做出准确和明确的诊断，免疫组织化学染色对于确认组织细胞起源至关重要。
