Sundersingh Shirley, Majhi Urmila, Seshadhri Ramakrishnan Ayloor, Tenali Gnana Sagar
Department of Pathology, Cancer Institute (W.I.A.), Chennai, India.
Indian J Pathol Microbiol. 2012 Apr-Jun;55(2):233-5. doi: 10.4103/0377-4929.97891.
We report a rare case of extranodal histiocytic sarcoma with multifocal gastrointestinal tract involvement, which has not been documented in the literature so far. A diagnosis of interdigitating dendritic cell/ histiocytic sarcoma was made on the preoperative gastric biopsy. Computed tomography scan revealed multifocal, circumferential gastrointestinal wall thickening involving the stomach and jejunal loops. Patient underwent distal gastrectomy with extended D1 dissection and proximal jejunal resection with gastrojejunostomy. Immunohistochemistry profile of both the gastric and jejunal tumors was similar to the preoperative gastric biopsy. The histiocytic origin of the tumor was confirmed by positive reaction of the tumor cells for CD 163. She received four cycles of CHOP chemotherapy, and is free of disease three years, following surgery.
我们报告了一例罕见的结外组织细胞肉瘤，累及多灶性胃肠道，目前文献中尚无相关记载。术前胃活检诊断为指突状树突状细胞/组织细胞肉瘤。计算机断层扫描显示多灶性、环形胃肠道壁增厚，累及胃和空肠袢。患者接受了远端胃切除术及扩大的D1清扫术和近端空肠切除术并进行了胃空肠吻合术。胃和空肠肿瘤的免疫组织化学特征与术前胃活检相似。肿瘤细胞对CD 163呈阳性反应，证实了肿瘤的组织细胞起源。她接受了四个周期的CHOP化疗，术后三年无疾病复发。
