Hong Jin Hee, Seo Dong Dae, Jeon Tae Joo, Oh Tae-Hoon, Shin Won Chang, Choi Won-Choong, Cho Hyun Sun
Departments of Internal Medicine, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea.
Korean J Gastroenterol. 2010 Feb;55(2):133-8. doi: 10.4166/kjg.2010.55.2.133.
Spontaneous regression of hepatocellular carcinoma (HCC) is extremely rare. We report a case of 67-year-old man having HBV-associated HCC with multiple lung metastases which regressed spontaneously. The patient had single liver mass and received surgical resection. The mass was confirmed as HCC histopathologically. Nine years after surgical resection, a 3.3 cm sized recurred HCC was detected on the resection margin in CT scan. Transarterial chemoembolization (TACE) was performed 3 times, and lung metastases developed thereafter. The patient received 2 more sessions of TACE, however, metastatic lung nodules were in progress very rapidly. We decided to stop TACE and followed the patient regularly without any anti-cancer treatment. Nine months after development of lung metastasis, the size and number of metastatic lung nodules decreased and were not detected anymore after 14 months. Serum alpha-fetoprotein levels also decreased to normal range and no viable tumor was noted in the liver. The patient is still alive 12 years after the first diagnosis of HCC and 16 months after lung metastasis developed.
肝细胞癌（HCC）的自发消退极为罕见。我们报告一例67岁男性，患有乙型肝炎病毒相关的HCC并伴有多发肺转移，其肿瘤自发消退。该患者有单个肝脏肿块并接受了手术切除。病理组织学证实肿块为HCC。手术切除9年后，CT扫描在切除边缘发现一个3.3厘米大小的复发性HCC。进行了3次经动脉化疗栓塞术（TACE），此后出现了肺转移。患者又接受了2次TACE治疗，然而，肺转移结节进展非常迅速。我们决定停止TACE治疗，并在未进行任何抗癌治疗的情况下定期随访该患者。肺转移发生9个月后，肺转移结节的大小和数量减少，14个月后不再被检测到。血清甲胎蛋白水平也降至正常范围，肝脏中未发现存活肿瘤。该患者在首次诊断为HCC后12年以及肺转移发生后16个月仍然存活。
